PRMT5 Restricts Hepatitis B Virus Replication via Epigenetic Repression of cccDNA Transcription and Interference with pgRNA Encapsidation. Zhang W, Chen J, Wu M, Zhang X, Zhang M, Yue L, Li Y, Liu J, Li B, Shen F, Wang Y, Bai L, Protzer U, Levrero M, Yuan Z. Hepatology. 2017 Feb 25. doi: 10.1002/hep.29133.
Genome-wide identification of direct HBx genomic targets. Guerrieri F, Belloni L, D'Andrea D, Pediconi N, Le Pera L, Testoni B, Scisciani C, Floriot O, Zoulim F, Tramontano A, Levrero M. BMC Genomics. 2017 Feb 17;18(1):184. doi: 10.1186/s12864-017-3561-5.
Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B. Fisicaro P, Barili V, Montanini B, Acerbi G, Ferracin M, Guerrieri F, Salerno D, Boni C, Massari M, Cavallo MC, Grossi G, Giuberti T, Lampertico P, Missale G, Levrero M, Ottonello S, Ferrari C. Nat Med. 2017 Feb 6. doi: 10.1038/nm.4275.
Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B patients. Lebossé F, Testoni B, Fresquet J, Facchetti F, Galmozzi E, Fournier M, Hervieu V, Berthillon P, Berby F, Bordes I, Durantel D, Levrero M, Lampertico P, Zoulim F. J Hepatol. 2016 Dec 30. pii: S0168-8278(16)30757-7. doi: 10.1016/j.jhep.2016.12.024.
HBV cure: why, how, when? Levrero M, Testoni B, Zoulim F. Curr Opin Virol. 2016 Jun;18:135-43. doi: 10.1016/j.coviro.2016.06.003. Review.
The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells. Nunn AD, Scopigno T, Pediconi N, Levrero M, Hagman H, Kiskis J, Enejder A. Sci Rep. 2016 Jun 20;6:28025. doi: 10.1038/srep28025.
Current treatments for chronic hepatitis B virus infections. Zoulim F, Lebossé F, Levrero M. Curr Opin Virol. 2016 Jun;18:109-16. doi: 10.1016/j.coviro.2016.06.004. Review.
Aiming for cure in HBV and HDV infection. Petersen J, Thompson AJ, Levrero M. J Hepatol. 2016 Oct;65(4):835-48. doi: 10.1016/j.jhep.2016.05.043. Review.
Mechanisms of HBV-induced hepatocellular carcinoma. Levrero M, Zucman-Rossi J. J Hepatol. 2016 Apr;64(1 Suppl):S84-101. doi: 10.1016/j.jhep.2016.02.021. Review.
IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome. Palumbo GA, Scisciani C, Pediconi N, Lupacchini L, Alfalate D, Guerrieri F, Calvo L, Salerno D, Di Cocco S, Levrero M, Belloni L. PLoS One. 2015 Nov 18;10(11):e0142599. doi: 10.1371/journal.pone.0142599.
Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes. Testoni B, Durantel D, Lebossé F, Fresquet J, Helle F, Negro F, Donato MF, Levrero M, Zoulim F. Gut. 2016 Apr;65(4):672-82. doi: 10.1136/gutjnl-2014-309011.
Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure. Zeisel MB, Lucifora J, Mason WS, Sureau C, Beck J, Levrero M, Kann M, Knolle PA, Benkirane M, Durantel D, Michel ML, Autran B, Cosset FL, Strick-Marchand H, Trépo C, Kao JH, Carrat F, Lacombe K, Schinazi RF, Barré-Sinoussi F, Delfraissy JF, Zoulim F. Gut. 2015 Aug;64(8):1314-26. doi: 10.1136/gutjnl-2014-308943. Review.
TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy. Costanzo A, Pediconi N, Narcisi A, Guerrieri F, Belloni L, Fausti F, Botti E, Levrero M. FEBS Lett. 2014 Aug 19;588(16):2590-9. doi: 10.1016/j.febslet.2014.06.047.
HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment. Benzoubir N, Lejamtel C, Battaglia S, Testoni B, Benassi B, Gondeau C, Perrin-Cocon L, Desterke C, Thiers V, Samuel D, Levrero M, Bréchot C, Bourgeade MF. J Hepatol. 2013 Dec;59(6):1160-8. doi: 10.1016/j.jhep.2013.07.036.
Position paper of the Italian Association for the Study of the Liver (AISF): the multidisciplinary clinical approach to hepatocellular carcinoma. Italian Association for the Study of the Liver (AISF).; AISF Expert Panel.; AISF Coordinating Committee., Bolondi L, Cillo U, Colombo M, Craxì A, Farinati F, Giannini EG, Golfieri R, Levrero M, Pinna AD, Piscaglia F, Raimondo G, Trevisani F, Bruno R, Caraceni P, Ciancio A, Coco B, Fraquelli M, Rendina M, Squadrito G, Toniutto P. Dig Liver Dis. 2013 Sep;45(9):712-23. doi: 10.1016/j.dld.2013.01.012.
Molecular mechanisms of HBV-associated hepatocarcinogenesis. Guerrieri F, Belloni L, Pediconi N, Levrero M. Semin Liver Dis. 2013 May;33(2):147-56. doi: 10.1055/s-0033-1345721. Review.
Mechanism of action of ribavirin in anti-HCV regimens: new insights for an age-old question? Testoni B, Levrero M, Durantel D. Gut. 2014 Jan;63(1):3-4. doi: 10.1136/gutjnl-2013-304528.