Membres et publications

Christophe CAUX, DR2 INSERM, CRCL
e-mail: christophe.caux@lyon.unicancer.fr
Pour plus d'informations: cliquez ici

  • Le Mercier I, Poujol D, Sanlaville A, Sisirak V, Gobert M, Durand I, Dubois B, Treilleux I, Marvel J, Vlach J, Blay JY, Bendriss-Vermare N, Caux C, Puisieux I, Goutagny N. Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment. Cancer Res. 2013 Aug 1;73(15):4629-40.
  • Sisirak V, Faget J, Gobert M, Goutagny N, Vey N, Treilleux I, Renaudineau S, Poyet G, Labidi-Galy SI, Goddard-Leon S, Durand I, Le Mercier I, Bajard A, Bachelot T, Puisieux A, Puisieux I, Blay JY, Ménétrier-Caux C, Caux C, Bendriss-Vermare N. Impaired IFN-α production by plasmacytoid dendritic cells favors regulatory T-cell expansion that may contribute to breast cancer progression. Cancer Res. 2012 Oct 15;72(20):5188-97
  • Labidi-Galy SI, Sisirak V, Meeus P, Gobert M, Treilleux I, Bajard A, Combes JD, Faget J, Mithieux F, Cassignol A, Tredan O, Durand I, Ménétrier-Caux C, Caux C, Blay JY, Ray-Coquard I, Bendriss-Vermare N.Quantitative and functional alterations of plasmacytoid dendritic cells contribute to immune tolerance in ovarian cancer. Cancer Res. 2011 Aug 15;71(16):5423-34.
  • Hirsch I, Caux C, Hasan U, Bendriss-Vermare N, Olive D. Impaired Toll-like receptor 7 and 9 signaling: from chronic viral infections to cancer. Trends Immunol. 2010 Oct;31(10):391-7.
  • Perrot I, Deauvieau F, Massacrier C, Hughes N, Garrone P, Durand I, Demaria O, Viaud N, Gauthier L, Blery M, Bonnefoy-Berard N, Morel Y, Tschopp J, Alexopoulou L, Trinchieri G, Paturel C, Caux C. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. J Immunol. 2010 Aug 15;185(4):2080-8.

Nadege GOUTAGNY, chercheur post-doctorant, CRCL
e-mail: nadege.goutagny@lyon.unicancer.fr
Pour plus d'informations: cliquez ici

  • Hasan UA, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, Carreira C, Hussain I, Müller M, Taylor-Papadimitriou J, Picard D, Sylla BS, Trinchieri G, Medzhitov R, Tommasino M. The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med. 2013 Jul 1;210(7):1369-87.
  • Le Mercier I, Poujol D, Sanlaville A, Sisirak V, Gobert M, Durand I, Dubois B, Treilleux I, Marvel J, Vlach J, Blay JY, Bendriss-Vermare N, Caux C, Puisieux I, Goutagny N. Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment. Cancer Res. 2013 Aug 1;73(15):4629-40.
  • Goutagny N, Estornes Y, Hasan U, Lebecque S, Caux C. Targeting pattern recognition receptors in cancer immunotherapy. Target Oncol. 2012 Mar;7(1):29-54.
  • Goutagny N, Jiang Z, Tian J, Parroche P, Schickli J, Monks BG, Ulbrandt N, Ji H, Kiener PA, Coyle AJ, Fitzgerald KA. Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein. J Immunol. 2010 Feb 1;184(3):1168-79.
  • Goutagny N, Fitzgerald KA. Pattern recognition receptors: an update.Expert Rev Clin Immunol. 2006 Jul;2(4):569-83.

Uzma HASAN, CR1 INSERM, CIRI
e-mail: uzma.hasan@inserm.fr
Pour plus d'informations: cliquez ici

  • Hasan UA, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, Carreira C, Hussain I, Müller M, Taylor-Papadimitriou J, Picard D, Sylla BS, Trinchieri G, Medzhitov R, Tommasino M. The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med. 2013 Jul 1;210(7):1369-87.
  • Shahzad N, Shuda M, Gheit T, Kwun HJ, Cornet I, Saidj D, Zannetti C, Hasan UA, Chang Y, Moore PS, Accardi R, Tommasino M. The T Antigen locus of Merkel Cell Polyomavirus Down-regulates Human Toll-like Receptor 9 Expression. J Virol. 2013 Sep 25.
  • Salcedo R, Cataisson C, Hasan UA, Yuspa SH, Trinchieri G. MyD88 and its divergent toll in carcinogenesis. Trends Immunol. 2013 Aug;34(8):379-89.
  • Vincent IE, Zannetti C, Lucifora J, Norder H, Protzer U, Hainaut P, Zoulim F, Tommasino M, Trépo C, Hasan U and Chemin I. Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells. PLoS One.2011;6(10):e26315.
  • Fathallah I, Parroche P, Gruffat H, Zannetti C, Johansson H, Yue J, Manet E,Tommasino M, Sylla BS, Hasan UA. EBV latent membrane protein 1 is a negative regulator of TLR9. J Immunol. 2010 Dec 1;185(11):6439-47.

Thomas HENRY, CR1 INSERM, CIRI
e-mail: thomas.henry@inserm.fr
Pour plus d'informations: cliquez ici

  • Juruj C, Lelogeais V, Pierini R, Perret M, Py BF, Jamilloux Y, Broz P, Ader F, Faure M, Henry T. Caspase-1 activity affects AIM2 speck foramtion/stability through a negative feedback loop Frontiers in Cellular and Infection Microbiology, April 2013, Volume3, Article14, 1-11.
  • Jamilloux Y., Pierini R., Querenet M., Juruj C., Fauchais A.L., Jauberteau M.O., Jarraud S., Lina G., Etienne J., Roy C.R., Henry T., Davoust-Nataf N., Ader F. Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection.Glia, 2013 Jan 28
  • Pierini R., Juruj C., Perret M., Henry T. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages. Cell Death and Differentiation, 2012 May 4
  • Perret M, Badiou C, Lina G, Burbaud S, Benito Y, Bes M, Cottin V, Couzon F, Juruj C, Dauwalder O, Goutagny N, Diep BA , Vandenesch F, Henry T. Cross-talk between S. aureus Leukocidins-intoxicated macrophages and lung epithelial cells triggers IL-8 secretion in an inflammasome-dependent manner. Cellular Microbiology, 2012 Feb 14
  • Jones JW, Kayagaki N, Broz P, Henry T, Newton K, O'Rourke K, Chan S, Dong J, Qu Y, Roose-Girma M, Dixit VM, Monack DM. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. PNAS 2010 May 25;107(21):9771-6
  • Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. Journal of Experimental Medicine 2007 May 14;204(5):987-94

Marie-Cécile MICHALLET, CR1 CNRS, CRCL
e-mail: marie-cecile.michallet@lyon.unicancer.fr
Pour plus d'informations: cliquez ici

  • Pierini R, Perret M, Djebali S, Juruj C, Michallet MC, Förster I, Marvel J, Walzer T, Henry T. ASC controls IFN-γ levels in an IL-18-dependent manner in Caspase-1-deficient mice infected with Francisella novicida. J Immunol. 2013 Aug 23.
  • Michallet MC, Rota G, Maslowski K, Guarda G. Innate receptors for adaptive immunity. Curr Opin Microbiol. 2013 Jun;16(3):296-302.
  • Schmidt A, Schwerd T, Hamm W, Hellmuth J, Cui S, Wenzel M, Hoffmann FS, Michallet MC, Besch R, Hopfner KP, Endres S, Rothenfusser S. 5'-triphosphate RNA requires base-paired structures to activate anti-viral signaling via RIG-I. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12067-72.
  • Ermolaeva MA, Michallet MC, Papadopoulou N, Utermöhlen O, Kranidioti X, Kollias G, Tschopp J and Pasparakis M. Role of TRADD in TNFRI-signaling and in TRIF-dependent inflammatory responses. Nat Immunol. 2008 Sep;9(9):1037-46.
  • Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, König M, Kalinke U, Pasparakis M and Tschopp J. TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity. 2008 May;28(5):651-61.

Peggy PARROCHE, chercheur post-doctorant, CIRI
e-mail: peggy.parroche@inserm.fr
Pour plus d'informations: cliquez ici

  • Hasan UA, Zannetti C, Parroche P, Goutagny N, Malfroy M, Roblot G, Carreira C, Hussain I, Müller M, Taylor-Papadimitriou J, Picard D, Sylla BS, Trinchieri G, Medzhitov R, Tommasino M.J Exp Med. 2013 Jul 1;210(7):1369-87.
  • Fathallah I, Parroche P, Gruffat H, Zannetti C, Johansson H, Yue J, Manet E, Tommasino M, Sylla BS, Hasan UA. J Immunol. 2010 Dec 1;185(11):6439-47. doi: 10.4049/jimmunol.0903459. Epub 2010 Oct 27.
  • Franklin BS, Parroche P, Ataíde MA, Lauw F, Ropert C, de Oliveira RB, Pereira D, Tada MS, Nogueira P, da Silva LH, Bjorkbacka H, Golenbock DT, Gazzinelli RT.Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5789-94. doi: 10.1073/pnas.0809742106. Epub 2009 Mar 18.
  • Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ.Nat Immunol. 2007 May;8(5):487-96. Epub 2007 Apr 8. Erratum in: Nat Immunol. 2007 Jul;8(7):780.
  • Parroche P, Lauw FN, Goutagny N, Latz E, Monks BG, Visintin A, Halmen KA, Lamphier M, Olivier M, Bartholomeu DC, Gazzinelli RT, Golenbock DT. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1919-24. Epub 2007 Jan 29.

Virginie PETRILLI, CR1 CNRS, CRCL
e-mail: virginie.petrilli@lyon.unicancer.fr
Pour plus d'informations: cliquez ici

  • Erener S, Pétrilli V, Kassner I, Minotti R, Castillo R, Santoro R., Hassa PO, Tschopp J and Hottiger MO. Inflammasome Activated Caspase 7 Cleaves PARP1 to Enhance NF-κB Dependent Transcription. Molecular Cell. 2012 Apr 27;46(2):200-11.
  • Kool M., Pétrilli V., De Smedt T., Rolaz A., Hammad H., van Nimwegen M., Bergen I., Castillo R., Lambrecht B.N., Tschopp J. Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol. (2008) sept 15 ;181(6):3755-9.
  • Muruve D.A., Pétrilli V., Zaiss A.K., White L.R., Clark S.A., Ross P.J., Parks R.J., and Tschopp J. Recognition of cytosolic microbial and host DNA by the inflammasome triggers an innate immune response. Nature (2008) Mar 6;452(7183):103-7. 
  • Dostert C., Pétrilli V., Van Bruggen R., Steele C., Mossman B.T. and Tschopp J. The Nalp3 inflammasome senses asbestos and silica and initiates innate immune responses. Science (2008) May 2;320(5876):674-7.
  • Pétrilli V., Papin S., Dostert C., Mayor A., and Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. (2007) Sep;14(9):1583-9.
CENTRE DE RECHERCHE EN CANCEROLOGIE DE LYON (CRCL)
UMR INSERM 1052 CNRS 5286 - CENTRE LEON BERARD
Copyright 2011. CRCL
SUIVEZ LES ACTUALITES
DU CRCL SUR TWITTER :