CONTACT

Julien MARIE, Chef d'équipe
julien.marie@inserm.fr

Stéphanie RODRIGUEZ, Lab Manager
stephanie.rodriguez@lyon.unicancer.fr
04 26 55 67 25

Bâtiment Cheney B

LAB MANAGER POSITION AVAILABLE
More Information

POST-DOC POSITIONS AVAILABLE 
Gut immunology

Skin immunology

Rodriguez Stéphanie
Soudja Saidi, PhD
Hernandez-Vargas Hector
Lainé Alexandra, PhD
Goldsmith Chloé, PhD
Apostolov Apostol, PhD
Benech Nicolas, MD

Gastroenterologist, PhD student
nicolas.benech@inserm.fr

Igalouzene Ramdane
Labiad Ossama
- Alumni
  • Farhan Cyprian, PhD 
  • Colin Havenar-Daughton, PhD
  • Mark McCarron, PhD
  • Ana Hennino, PhD
  • David Bauché, PhD
  • Elise Macho-Fernandez, PhD
  • Anne Ruiz, MS
  • Céline Garcia, MS
  • Cyril Deceneux, MS
  • Olivier Fesneau, PhD
Marie Lab summer break 2017
Voir les objectifs et projets Voir les publications

OBJECTIVES

The immune system has to be ignorant against the self-cells to avoid autoimmunity, but it should also be able to eliminate the self-cells that are noxious for the organism such as tumor cells.  the immune system should be tolerant to the microbiota that established symbiotic exchange with the organism. Transforming Growth Factor beta (TGF-β) is  highly conserved cytokine present in all mammals. TGF-β  has been described as key regulatory cytokine of the immune system. Interestingly, this cytokine is highly produced by the tumor micro-environment and it is known to contribute also to tumor growth. Our previous works revealed that within the immune system the target-cells of the regulatory effects of TGF-β are T lymphocytes (Immunity 2006) and that TGF-β signaling represses their activation against self-cells.  We  reported that TGF-β influences the differentiation of memory cells ( Nature Com 2014, Immunity 2012), NKT ( J. Exp Med 2009, Blood 2012). We alos revealed that TGF-β prevents from autoantibody development by regulating T follicular heper cells differentiation ( J. Clin invest 2014). Our works alos revealed a key role for TGF-β in Foxp3 regulatory T cell biology (J. Exp. Med 2009 Immunity 2015).  Our lab developed several novative tools  to study the molecular and cellular mechanisms responsible for the control of peripheral T cell tolerance to self-cells by TGF-β and analyses their effects on autoimmune diseases and tumor development.

 
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PUBLICATIONS

Selected publications

The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells.
Agliata I, Fernandez-Jimenez N, Goldsmith C, Marie JC, Bilbao JR, Dante R, Hernandez-Vargas H. Epigenetics. 2020 Apr 12:1-15. doi: 10.1080/15592294.2020.1748916.  PMID: 32281463

ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response
Bouchet M, Lainé A, Boyault C, Proponnet-Guerault M, Meugnier E, Bouazza L, Kan CWS, Geraci S, El-Moghrabi S, Hernandez-Vargas H, Benetollo C, Yoshiko Y, Duterque-Coquillaud M, Clézardin P, Marie JC, Bonnelye E. Cancer Res. 2020

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

Ferreira C, Barros L, Baptista M, Blankenhaus B, Barros A, Figueiredo-Campos P, Konjar S, Lainé A, Kamenjarin N, Stojanovic A, Cerwenka A, Probst HC, Marie JC, Veldhoen M. Nature Immunol. 2020

Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection
McCarron MJ, Irla M, Sergé A, Soudja SM, Marie JC. Nature Com. 2019 Dec 19;10(1):5690. 

Cellular Stress  in the Context of an Inflammatory Environment Supports TGF-b Indepdendent T Helper-17 Differentiation
Brucklacher-Waldert V, Ferreira C, Stebegg M, Fesneau O., Innocnetin S, Marie J.C, Veldhoen M, Cell report 2017

Transforming growth fatcor b a master regulator of the gut microbiota and immune cell interactions (Review article)

Bauché D. and Marie JC, Clin. Trans. Immunology 2017

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation
Worthington J.J ,  Kelly A. , Smedley C., Bauché D.,  Campbell S,  Marie J.C, Travis M.A, Immunity  2015 

NK1.1(+) CD8(+) T cells escape TGF-β control and contribute to early microbial pathogen response.
Ruiz A.L Soudja SM, Deceneux C, Lauvau G. and Marie JC. Nature Com 2014

TGF-β prevents T follicular helper cell accumulation and B cell autoreactivity.
McCarron M.J. and  Marie JC, Journal Clin. Invest. 2014

Inflammatory Monocytes Activate Memory CD8(+) T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion.
Soudja SM, Ruiz AL, Marie JC, Lauvau G. Immunity. 2012. 

Development and function of murine RORγt+ iNKT cells are under TGF-β control.
Havenar-Daughton C, Li S, Benlagha K, Marie JC. Blood. 2012 .

iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC. J Exp Med. 2009

Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC. Genesis. 2008

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY. Immunity. 2006

TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells.
Marie JC, Letterio JJ, Gavin M, Rudensky AY. J Exp Med. 2005

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