CONTACT

Virginie PETRILLI
Principal Investigator

virginie.petrilli
(at)lyon.unicancer.fr


+33 (0)4 26 55 67 96

Cheney D - 6th floor
Centre Léon Bérard

PETRILLI Virginie
Chef d'équipe, CR1 CNRS, HDR
virginie.petrilli(at)lyon.unicancer.fr
BODNAR Mélanie
GUEY Baptiste
HACOT Sabine
THOMAS Meryl
VARELA Christine
GORRY Julie

Master 2 student

Voir les objectifs et projets Voir les publications

OBJECTIVES

Inflammasomes are newly described molecular platforms that control the biological activity of 2 major proinflammatory cytokines: the interleukin-1beta (IL-1β) and interleukin-18 (IL-18). Inflammasomes play major roles in innate immunity by activating an inflammation in response to pathogens but also to self-danger signals. They are composed of an innate immune receptor, for instance, NLRP3, an adaptor ASC, and the inflammatory caspase-1. In fact, the NLRP3 inflammasome was shown to play an essential role against infection by adenovirus, influenza virus, Staphyloccus aureus or Candida albicans but also to play a deleterious role in autoinflammatory disorders like cryopyrinopathies, gout disease and type 2 diabetes. IL-1β is the main effector for these pathologies. Beside, inflammation was shown to support tumorigenesis as seen for breast and lung cancers. However, little is known about a role for the NLRP3 inflammasome in the pathophysiology of cancer. Our goal is to decipher the contribution of the NLRP3 inflammasome to tumour development.

PUBLICATIONS

Guey B, Bodnar M, Manié SN, Tardivel A and Petrilli V. Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function. Proc Natl Acad Sci U S A. published ahead of print November 17, 2014, doi:10.1073/pnas.1415756111.

Huber AL, Lebeau J, Guillaumot P,  Petrilli V, Malek M,  Chilloux J, Fauvet F , Payen L, Kfoury A, Renno T, Chevet E and Manié SN. p58(IPK)-mediated attenuation of the pro-apoptotic PERK-CHOP pathway allows malignant progression upon low glucose. Mol Cell. 2013 Mar 28;49(6):1049-59.

Erener S, Petrilli V, Kassner I, Minotti R, Castillo R, Santoro R., Hassa PO, Tschopp J and Hottiger MO. Inflammasome Activated Caspase 7 Cleaves PARP1 to Enhance NF-κB Dependent Transcription. Mol Cell. (2012) Apr 27;46(2):200-11.

Sharp FA, Ruane D, Claass B, Creagh E, Harris J, Malyala P, Singh M, O'Hagan DT, Pétrilli V, Tschopp J, O'Neill LA, Lavelle EC. Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome. Proc Natl Acad Sci U S A. (2009) Jan 20;106(3):870-5.

Gasse P, Riteau N, Charron S, Girre S, Fick L, Pétrilli V, Tschopp J, Lagente V, Quesniaux VF, Ryffel B, Couillin I. Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis. Am J Respir Crit Care Med. (2009) May 15;179(10):903-13.

Kool M., Pétrilli V., De Smedt T., Rolaz A., Hammad H., van Nimwegen M., Bergen I., Castillo R., Lambrecht B.N., Tschopp J. Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J. Immunol. (2008) sept 15 ;181(6):3755-9.

Muruve D.A.*, Pétrilli V.*, Zaiss A.K., White L.R., Clark S.A., Ross P.J., Parks R.J., and Tschopp J. Recognition of cytosolic microbial and host DNA by the inflammasome triggers an innate immune response. Nature (2008) Mar 6;452(7183):103-7. * contributed equally to the work.

Dostert C., Pétrilli V., Van Bruggen R., Steele C., Mossman B.T. and Tschopp J. The Nalp3 inflammasome senses asbestos and silica and initiates innate immune responses. Science (2008) May 2;320(5876):674-7.

Pétrilli V., Papin S., Dostert C., Mayor A., and Tschopp J. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. (2007) Sep;14(9):1583-9.

Reviews & Books
Bodnar M and Petrilli V. New insight in caspase-11 functions in noncanonical inflammasome signalling. Inflammasome (2014). DOI: 10.2478/infl-2014-0001.degruyter.com.

Pétrilli V., Dostert C., Muruve D.A. and Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol. (2007) Dec;19(6):615-22

Progress in Inflammation Research, “The inflammasomes”, editors Couillin/Pétrilli/Martinon. 2011. Springer Birkhäuser Basel AG. ISBN 978-3-0348-0147-8

Material and reagent info

Communauté Innate Sensors

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