CONTACT

Toufic RENNO
toufic.renno@lyon.unicancer.fr

+33 4 69 16 66 29

Centre Léon Bérard
Cheney D - 6th floor
28 rue Laennec
69373 Lyon Cedex 08
France

 

Toufic Renno's team includes five different groups : 

-Serge Lebecque's Group

-Serge Manié's Group

-Toufic Renno's Group

-S.Ansieau/N.Aznar's Group

-Cédric Chaveroux's Group
RENNO Toufic
LEBECQUE Serge
MANIE Serge
ANSIEAU Stéphane
COSTE Isabelle
CHAVEROUX Cédric
AZNAR Nicolas
VIRARD François
DURET Cedric
MAGADOUX Lea
FAUVRE Joelle
DRAGIC Helena
FERRARO-PEYRET Carole
DENEUVE Sophie
Praticien spécialiste des CLCC
sophie.deneuve@lyon.unicancer.fr
PACHERO Yves
PU-PH
GODART Matthias
Entrepreneur projet Stemness Research SATT/Pulsalys
matthias.godart@lyon.unicancer.fr
PIECYK Marie
Voir les objectifs et projets Voir les publications
FOUNDING

Ligue de lutte contre le cancer

ANR-Blanc

INCa-Libre

Cancéropôle CLARA - « Preuve de Concept »

ARC-Projets

LYRIC


OBJECTIVES

The main objective of the team is to elucidate the contribution of innate immune signalling proteins to cellular transformation or to the apoptosis of tumor cells. Moreover, we are working to define mechanisms allowing cells that are subjected to an oncogenic stress to adapt to the energetic and metabolic constraints resulting from this stress. We have developed several genetic animal models to address the above questions in vivo, and pre-clinical studies are ongoing to evaluate potential therapeutic targets resulting from our studies.

PUBLICATIONS

Bonnin M, Fares N, Testoni B, Estornes Y, Weber K, Vanbervliet B, Lefrançois L, Garcia A, Kfoury A, Pez F, Coste I, Saintigny P, Viari A, Lang K, Guey B, Hervieu V, Bancel B, Bartoch B, Durantel D, Renno T, Merle P, Lebecque S. Toll-like receptor 3 downregulation is an escape mechanism from apoptosis during hepatocarcinogenesis. J Hepatol. 2019 Oct;71(4):763-772.

 

Ear J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J, Goel A, Janssen KP, Aznar N, Ghosh P. Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Scientific Reports. 2019 Aug 20;9(1):12124.

 

Bret D, Chappuis V, Poncet D, Ducray F, Silva K, Mion F, Vasiljevic A, Ferraro-Peyret C, Mottolese C, Leblond P, Gabut M, Frappaz D, Streichenberger N, Meyronet D, Bringuier PP, Barritault M. A Multiplex Quantitative Reverse Transcription Polymerase Chain Reaction Assay for the Detection of KIAA1549-BRAF Fusion Transcripts in Formalin-Fixed Paraffin-Embedded Pilocytic Astrocytomas. Mol Diagn Ther. 2019 Aug;23(4):537-545.

 

Calender A, Lim CX, Weichhart T, Buisson A, Besnard V, Rollat-Farnier PA, Bardel C, Roy P, Cottin V, Devouassoux G, Finat A, Pinson S, Lebecque S, Nunes H, Israel-Biet D, Bentaher A, Valeyre D, Pacheco Y; in the frame of GSF (Group Sarcoidosis France). Exome sequencing and pathogenicity network analysis of five French families implicate mTOR signalling and autophagy in familial sarcoidosis. Eur Respir J. 2019 Aug 1;54(2).

 

Dunkel Y, Reid A, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M, and Ghosh P.  Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma. Scientific Reports, 2018 Dec 21;8(1):18036.

 

Leung EY, Askarian-Amiri ME, Singleton DC, Ferraro-Peyret C, Joseph WR, Finlay GJ, Broom RJ, Kakadia PM, Bohlander SK, Marshall E, Baguley BC. Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations. Front Oncol. 2018 Oct 12;8:425.

 

Alkurdi L, Virard F, Vanbervliet B, Weber K, Toscano F, Bonnin M, Le Stang N, Lantuejoul S, Micheau O, Renno T, Lebecque S, Estornes Y. Release of c-FLIP brake selectively sensitizes human cancer cells to TLR3-mediated apoptosis. Cell Death Dis. 2018 Aug 29;9(9):874.

 

Estornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, Lebecque S, Vandenabeele P, Bertrand MJM. N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis. Cell Death Dis. 2018 May 1;9(5):494.

 

Garcia J, Forestier J, Dusserre E, Wozny AS, Geiguer F, Merle P, Tissot C, Ferraro-Peyret C, Jones FS, Edelstein DL, Cheynet V, Bardel C, Vilchez G, Xu Z, Bringuier PP, Barritault M, Brengle-Pesce K, Guillet M, Chauvenet M, Manship B, Brevet M, Rodriguez-Lafrasse C, Hervieu V, Couraud S, Walter T, Payen L. Cross-platform comparison for the detection of RAS mutations in cfDNA (ddPCR Biorad detection assay, BEAMing assay, and NGS strategy). Oncotarget. 2018 Apr 20;9(30):21122-21131.

 

Calender A, Rollat Farnier PA, Buisson A, Pinson S, Bentaher A, Lebecque S, Corvol H, Abou Taam R, Houdouin V, Bardel C, Roy P, Devouassoux G, Cottin V, Seve P, Bernaudin JF, Lim CX, Weichhart T, Valeyre D, Pacheco Y, Clement A, Nathan N; in the frame of GSF (Groupe Sarcoïdose France). Whole exome sequencing in three families segregating a pediatric case of sarcoidosis. BMC Med Genomics. 2018 Mar 6;11(1):23.

 

Pacheco Y, Ponchon M, Lebecque S, Calender A, Bernaudin JF, Valeyre D, Iglarz M, Strasser DS, Studer R, Freti D, Renno T, Bentaher A. Granulomatous lung inflammation is nanoparticle type-dependent. Exp Lung Res. 2018 Feb;44(1):25-39.

 

Bollard J, Patte C, Massoma P, Goddard I, Gadot N, Benslama N, Hervieu V, Ferraro-Peyret C, Cordier-Bussat M, Scoazec JY, Roche C, Walter T, Vercherat C. Combinatorial Treatment with mTOR Inhibitors and Streptozotocin Leads to Synergistic In Vitro and In Vivo Antitumor Effects in Insulinoma Cells. Mol Cancer Ther. 2018 Jan;17(1):60-72.

 

Leung EY, Askarian-Amiri ME, Sarkar D, Ferraro-Peyret C, Joseph WR, Finlay GJ, Baguley BC. Endocrine Therapy of Estrogen Receptor-Positive Breast Cancer Cells: Early Differential Effects on Stem Cell Markers. Front Oncol. 2017 Sep 4;7:184.

 

Freis P, Bollard J, Lebeau J, Massoma P, Fauvre J, Vercherat C, Walter T, Manié S, Roche C, Scoazec JY, Ferraro-Peyret C. mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines. Oncotarget. 2017 Mar 28;8(13):20974-20987

 

Pacheco Y, Calender A, Israël-Biet D, Roy P, Lebecque S, Cottin V, Bouvry D, Nunes H, Sève P, Pérard L, Devouassoux G, Freymond N, Khouatra C, Wallaert B, Lamy R, Elsensohn MH, Bardel C, Valeyre D; GSF group. Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort. Orphanet J Rare Dis. 2016 Dec 3;11(1):165.

 

Picco V, Coste I, Giraud-Panis MJ, Renno T, Gilson E, Pagès G. ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2. Oncotarget. 2016 Jul 19;7(29):46615-46627

 

Chaveroux C, Sarcinelli C, Barbet V, Belfeki S, Barthelaix A, Ferraro-Peyret C, Lebecque S, Renno T, Bruhat A, Fafournoux P, Manié SN. Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway. Sci Rep. 2016 Jun 3;6:27278

 

Combaz-Lair C, Galateau-Sallé F, McLeer-Florin A, Le Stang N, David-Boudet L, Duruisseaux M, Ferretti GR, Brambilla E, Lebecque S, Lantuejoul S. Immune biomarkers PD-1/PD-L1 and TLR3 in malignant pleural mesotheliomas. Hum Pathol. 2016 Jun;52:9-18

 

Boudra R, Lagrafeuille R, Lours-Calet C, de Joussineau C, Loubeau-Legros G, Chaveroux C, Saru JP, Baron S, Morel L, Beaudoin C. mTOR transcriptionally and post-transcriptionally regulates Npm1 gene expression to contribute to enhanced proliferation in cells with Pten inactivation. Cell Cycle. 2016 May 18;15(10):1352-62

 

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 12, 1-222

 

Virard F, Cousty S, Cambus JP, Valentin A, Kémoun P, Clément F. Cold Atmospheric Plasma Induces a Predominantly Necrotic Cell Death via the Microenvironment. PLoS One. 2015 Aug 14;10(8):e0133120

 

Al Akoum C, Akl I, Rouas R, Fayyad-Kazan M, Falha L, Renno T, Burny A, Lewalle P, Fayyad-Kazan H, Badran. NFAT-1, Sp-1, Sp-3, and miR-21: New regulators of chemokine C receptor 7 expression in mature human dendritic cells. Hum Immunol. 2015 May;76(5):307-17

 

Prod'Homme V, Boyer L, Dubois N, Mallavialle A, Munro P, Mouska X, Coste I, Rottapel R, Tartare-Deckert S, Deckert M. Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages. J Clin Invest. 2015 Apr;125(4):1396-400

 

Kfoury A, Virard F, Renno T, Coste I. Dual function of MyD88 in inflammation and oncogenesis : implications for therapeutic intervention. Curr Opin Oncol. 2014 Jan;26(1):86-91

 

Dejeans N, Manié S, Hetz C, Bard F, Hupp T, Agostinis P, Samali A, Chevet E. Addicted to secrete-novelconcepts and targets in cancer therapy. Trends Mol Med. 2014 Jan 20. pii: S1471-4914(13)00213-X

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