GENERAL AIM OF THE DEPARTMENT
Director : Alain Puisieux
Deputy Director : Mathieu Gabut
The genetic and functional diversity of malignant cells constituting a given tumor (intratumor heterogeneity) and the plasticity of cancer cells are crucial mechanisms involved in the onset of tumorigenesis and in tumor development. These mechanisms also participate in post-treatment drug resistance and in cancer relapse.
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The aim of the teams in this Department is to characterize the molecular mechanisms responsible for intratumor heterogeneity, at the genetic level, as well as at the phenotypic or functional levels, with a particular interest in the characterization of cancer stem cells and in their evolution during the development of the tumor.
The main types of cancers studied by these teams are breast cancers, melanomas, gastrointestinal cancers and glioblastomas.
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THIS DEPARTMENT IS COMPOSED OF 7 RESEARCH TEAMS
- EMT and cancer cell plasticity
Director Alain Puisieux
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- Nuclear domains and pathologies
Director Jean-Jacques Diaz
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- Oestrogen signaling and breast tumor
Director Muriel Le Romancer
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- Signaling, metabolism and tumor progression
Co-directors Ruth Rimokh & Germain Gillet
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- Transcriptome diversity in stem cells
Director Mathieu Gabut
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- Cellular reprogramming and oncogenesis
Director Fabrice Lavial
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- Development, cancer and stem cell
Director Michelina Plateroti
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- Emerging team "Cancer cell plasticity in melanoma"
Co-directors Julie Caramel & Stéphane Dalle
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- Emerging team "Biology of rare sarcomas"
Direction Franck Tirode
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- Emerging team "Integrated analysis of the dynamics of cancer"
Direction Pierre Saintigny
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