ACTUALITES

RECRUITMENT FOR THE POSITION OF DIRECTOR

The Cancer Research Center of Lyon announces the recruitment for the position of its Director.
Closing day for applications is June 15, 2018.
Please consult the full announcement on Nature Jobs.



SEMINARS

  • CRCL/CLB Seminar

The next seminar will take place Friday 9th of February in the ONCORA meeting room (Leon Berard Center, 2nd floor) :
We are pleased to welcome Erika Cosset (Department of Pathology and Immunology (PATIM), University of Geneva) for a seminar entitled : "Glut3 addiction is a druggable vulnerability for a moleculary defined subpopulation of glioblastoma"

SCIENTIFIC EVENTS

  • 3rd International CRCL Symposium

The 3rd CRCL Symposium took place in 25th-27th September 2017 ! Many thanks to our speakers, participants and sponsors, for their presence and support.

More information on our website available 
here.

Enjoy the highlights of the CRCL Symposium 2017 with the official video:

CRCL SYMPOSIUM 2017 from C.R.C.L on Vimeo.

OTHER

  • A new International Associated Laboratory (LIA)


The CRCL team of Alain Puisieux "EMT and cancer cell plasticity"  sucessfully applied to an Inserm call to develop an International Associated Laboratory together with the group of Frederic Holland "Molecular mechanisms of tumor progression", from the Victorian Comprehensive Cancer Cancer, University of Melbourne, Australia.

LATEST PUBLICATIONS

  • Cellular Pliancy and the Multistep Process of Tumorigenesis


This study has been directed by Alain Puisieux. 

Completion of early stages of tumorigenesis relies on the dynamic 
interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.
https://doi.org/10.1016/j.ccell.2018.01.007

  • Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of hu


This study has been performed by the "Nuclear domains and pathologies" team, directed by Jean-Jacques Diaz.
Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2′-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in rRNA. 2′-O-Me was shown to be essential for accurate and efficient protein synthesis in eukaryotic cells.

> MORE INFORMATION
doi: 10.1073/pnas.1707674114

JOB OPPORTUNITIES

  • Décembre 2017

L'équipe Anticorps Anticancer, dirigée par le Pr Charles Dumontet, recherche un post-doctorant pour un projet "d'évaluation préclinique d'un nouvel agent immunostimulant à visée thérapeutique dans les modèles de cancérologie". 
Plus d'informations

  • Octobre 2017

We are currently looking for postdoctoral researcher to join the “Activin Tumor Signaling” group of the Signaling, metabolism and tumor progression team headed by Ruth Rimokh/Germain Gillet at the Cancer Research Centre of Lyon (CRCL, France; http://www.crcl.fr). This team is part of the CRCL that will provide an excellent research environment including core facilities, support services as well as an international stimulating environment.
More information here

  • Aout 2017

Chef de Projet RHU cirB-RNA.
Le programme du RHU cirB-RNA s’intègre dans la dynamique de recherche autour du virus de l’hépatite B, la détection et la prise en charge de la maladie, coordonnée par les Professeurs Zoulim et Levrero.
Plus d'informations

CENTRE DE RECHERCHE EN CANCEROLOGIE DE LYON (CRCL)
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