ACTUALITES

SEMINARS

  • CRCL/CLB Seminar

The next seminar will take place on the 19th of October at 11.30am in the Jean-Louis Requin meeting room (Centre Léon Bérard, Cheney D). We are pleased to welcome Cédric Vaillant (Laboratoire de Physique UMR CNRS 5672, ENS Lyon). His talk will focus on "The folding landscape of the epigenome".

SCIENTIFIC EVENTS

  • 3rd International CRCL Symposium

The 3rd CRCL Symposium took place in 25th-27th September 2017 ! Many thanks to our speakers, participants and sponsors, for their presence and support.

More information on our website available 
here.

Enjoy the highlights of the CRCL Symposium 2017 with the official video:

CRCL SYMPOSIUM 2017 from C.R.C.L on Vimeo.

OTHER

  • A new International Associated Laboratory (LIA)


The CRCL team of Alain Puisieux "EMT and cancer cell plasticity"  sucessfully applied to an Inserm call to develop an International Associated Laboratory together with the group of Frederic Holland "Molecular mechanisms of tumor progression", from the Victorian Comprehensive Cancer Cancer, University of Melbourne, Australia.

LATEST PUBLICATIONS

  • Cellular Pliancy and the Multistep Process of Tumorigenesis


This study has been directed by Alain Puisieux. 

Completion of early stages of tumorigenesis relies on the dynamic 
interplay between the initiating oncogenic event and the cellular context. Here, we review recent findings indicating that each differentiation stage within a defined cellular lineage is associated with a unique susceptibility to malignant transformation when subjected to a specific oncogenic insult. This emerging notion, named cellular pliancy, provides a rationale for the short delay in the development of pediatric cancers of prenatal origin. It also highlights the critical role of cellular reprogramming in early steps of malignant transformation of adult differentiated cells and its impact on the natural history of tumorigenesis.
https://doi.org/10.1016/j.ccell.2018.01.007

  • Evidence for rRNA 2′-O-methylation plasticity: Control of intrinsic translational capabilities of hu


This study has been performed by the "Nuclear domains and pathologies" team, directed by Jean-Jacques Diaz.
Ribosomal RNAs (rRNAs) are main effectors of messenger RNA (mRNA) decoding, peptide-bond formation, and ribosome dynamics during translation. Ribose 2′-O-methylation (2′-O-Me) is the most abundant rRNA chemical modification, and displays a complex pattern in rRNA. 2′-O-Me was shown to be essential for accurate and efficient protein synthesis in eukaryotic cells.

> MORE INFORMATION
doi: 10.1073/pnas.1707674114

JOB OPPORTUNITIES

  • October 2018 - Research Associate Position

Open call for a research associate position in the team of Dr. G. Ichim at the CRCL (Lyon, France) for the study of mitochondrial regulation of cell death and non-lethal caspase activation with a wide-range of implication in cancer cell invasiveness, resistance to therapy or cancer stem cells.
More Information

  • September 2018 - Post-Doctoral position

The research laboratory on Viral Hepatitis, directed by Prof. F. Zoulim, is opening a 2-years Post-Doctoral position. The Viral Hepatitis team has a longstanding experience in the study of the mechanisms of HBV persistence and the identification of novel targets for antiviral therapy.
More Information

  • Septembre 2018 - Assistant Ingénieur ou Ingénieur d'Etude

Dans le cadre d’un projet de recherche, en partenariat avec un grand groupe pharmaceutique, portant sur les sous populations de lymphocytes T régulateurs dans les cancers du sein et l’identification de nouvelles cibles, l’équipe « Ciblage thérapeutique des cellules tumorales et de leur stroma immunitaire» du CRCL dirigée par le Dr C Caux recherche un Assistant Ingénieur ou un Ingénieur d'Etude.
Plus d'information

  • August 2018 - Postdoctoral position

A postdoctoral position in tumor immunology and immunotherapy is available in the team "Tumor immune surveillance and therapeutic targeting" (Dir. C.Caux).
More information

  • August 2018 - Ph.D Thesis offer

A thesis offer is available in the group of Pr. Raverot and Dr. Bertolino at the CRCL. The group focuses on the identification of new markers and molecular/cellular mechanisms that drives the tumorogenesis and agressive baheviour of pituitary tumours.
More information

  • August 2018 - Postdoctoral position

A postdoctoral position in molecular biology of sarcomas is available in the "Genetics, epigenetics and biology of sarcomas" group (Dir. Frank Tirode)
More information

  • July 2018 - Postdoctoral Position

A 2-years post-doctoral position for a highly motivated and talented postdoctoral fellow is available in the team of Dr Petrilli at the Cancer Research Centre of Lyon (CRCL) France.
More information.

  • April 2018 - Postdoctoral position

A postdoctoral position is available at the CRCL in the research team of Pr Massimo Levrero (Epigenomics and epigenetics of hepatocellular carcinomas) to work on the role of HBV proteins and IncRNAs in the molecular pathogenesis of HBV-related hepatocellular carcinomas. The position is open for 3 years. 
More information

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